uses of active Tapentadol 100 Mg Tablet for sale

active Tapentadol 100 Mg Tablet for sale, brand names Nucynta among others, is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI) Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours.^[3]

more to that, active Tapentadol 100 Mg Tablet for sale is similar to tramadol in its dual mechanism of action; namely, its ability to activate the mu opioid receptor and inhibit the reuptake of norepinephrine. Unlike tramadol, it has only weak effects on the reuptake of serotonin and is a significantly more potent opioid with no known active metabolites. active Tapentadol 100 Mg Tablet for sale is not a pro-drug and therefore does not rely on metabolism to produce its therapeutic effects; this makes it a useful moderate-potency analgesic option for patients who do not respond adequately to more commonly used opioids due to genetic disposition (poor metabolizers of CYP3A4 and CYP2D6), as well as providing a more consistent dosage-response range among the patient population.

The potency of active Tapentadol 100 Mg Tablet for sale is somewhere between that of tramadol and morphine,^[5] with an analgesic efficacy comparable to that of oxycodone despite a lower incidence of side effects.^[1] It is generally regarded as a moderately strong opioid.

active Tapentadol 100 Mg Tablet for sale was approved by the US FDA in November 2008,^[6] by the TGA of Australia in December 2010^[7] and by the MHRA of the UK in February 2011.^[8] In India, Central Drug Standard Control Organisation (CDSCO) approved tapentadol immediate-release (IR) preparations (50, 75 and 100 mg) for moderate to severe acute pain and extended-release (ER) preparations (50,100,150 and 200 mg) for severe acute pain in April 2011 and December 2013 respectively.

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Therapeutic indications of active Tapentadol 100 Mg Tablet for sale

An indication is a term used for the list of condition or symptom or illness for which active Tapentadol 100 Mg Tablet for sale is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. In addition, Now fever, headache and body pains are the indications of paracetamol. again, A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Tapentadol® ER (active Tapentadol 100 Mg Tablet for sale) is indicated for the management of:

pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate
neuropathic pain associated with diabetic peripheral neuropathy (DPN) in adults severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate.

Limitations of active Tapentadol 100 Mg Tablet for sale Usage

Because of the risks of addiction, abuse, and misuse with opioids, even at recommended doses, and because of the greater risks of overdose and death with extended-release opioid formulations, reserve Tapentadol® ER for use in patients for whom alternative treatment options (e.g., non-opioid analgesics or immediate-release opioids) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain.
Tapentadol® ER is not indicated as an as-needed (prn) analgesic.

active Tapentadol 100 Mg Tablet for sale(Tapentadol) is an opioid pain medication. An opioid is sometimes called a narcotic.

Tapentadol is used to treat moderate to severe pain.

The extended-release form of Tapentadol is for around-the-clock treatment of pain that is not controlled by other medicines. It is not for use on an as-needed basis for pain.

Tapentadol may also be used for purposes not listed in this medication guide.

Dosage (Posology) and method of administration active Tapentadol 100 Mg Tablet for sale

Tapentadol® oral solution is available in one concentration: 20 mg/mL.

Take care when prescribing and administering active Tapentadol 100 Mg Tablet for sale® oral solution to avoid dosing errors, which could result in accidental overdose and death. Take care to ensure the proper dose is communicated and dispensed. Include the dose in milliliters (mL) and milligrams (mg) when writing prescriptions. Always use the enclosed calibrated oral syringe when administering Tapentadol® oral solution to ensure the dose is measured and administered accurately.

Individualization Of Dosage

As with any opioid drug product, adjust the dosing regimen for each patient individually, taking into account the patient’s prior analgesic treatment experience. In the selection of the initial dose of Tapentadol, give attention to the following:

the total daily dose, potency and specific characteristics of the opioid the patient has been taking previously;
the reliability of the relative potency estimate used to calculate the equivalent morphine sulfate dose needed;
the patient’s degree of opioid tolerance;
the general condition and medical status of the patient;
concurrent medications;
the type and severity of the patient’s pain;
risk factors for abuse, addiction or diversion, including a prior history of abuse, addiction or diversion.

The following dosing recommendations, therefore, can only be considered suggested approaches to what is actually a series of clinical decisions over time in the management of the pain of each individual patient. Continual re-evaluation of the patient receiving Tapentadol is important, with special attention to the maintenance of pain control and the relative incidence of side effects associated with therapy. During chronic therapy, especially for non-cancer-related pain, periodically re-assess the continued need for the use of opioid analgesics.

During periods of changing analgesic requirements, including initial titration, frequent contact is recommended between physician, other members of the healthcare team, the patient, and the caregiver/family. Monitor the patient for signs of respiratory or central nervous system depression.

Initiation Of active Tapentadol 100 Mg Tablet for sale Therapy

The dose is 2.5 mL (equivalent to 50 mg), 3.75 mL (equivalent to 75 mg), or 5 mL (equivalent to 100 mg) every 4 to 6 hours depending upon pain intensity.

On the first day of dosing, the second dose may be administered as soon as one hour after the first dose, if adequate pain relief is not attained with the first dose. Subsequent dosing is 2.5 mL (equivalent to 50 mg), 3.75 mL (equivalent to 75 mg), or 5 mL (equivalent to 100 mg) every 4 to 6 hours and should be adjusted to maintain adequate analgesia with acceptable tolerability.

Daily doses greater than 700 mg on the first day of therapy and 600 mg on subsequent days have not been studied and are not recommended.

active Tapentadol 100 Mg Tablet for sale may be given with or without food.

Renal Impairment

Use of Tapentadol® in patients with severe renal impairment is not recommended.

No dosage adjustment is recommended in patients with mild or moderate renal impairment.

Hepatic Impairment

The safety and efficacy of Tapentadol® has not been studied in patients with severe hepatic impairment (Child-Pugh Score 10-15) and use in this population is not recommended.

Initiate treatment of patients with moderate hepatic impairment (Child-Pugh Score 7 to 9) with 50 mg no more frequently than once every 8 hours (maximum of three doses in 24 hours). Further treatment should reflect maintenance of analgesia with acceptable tolerability, to be achieved by either shortening or lengthening the dosing interval.

No dosage adjustment is recommended in patients with mild hepatic impairment (Child-Pugh Score 5 to 6).

Elderly Patients

In general, recommended dosing for elderly patients with normal renal and hepatic function is the same as for younger adult patients with normal renal and hepatic function. Because elderly patients are more likely to have decreased renal and hepatic function, consideration should be given to starting elderly patients with the lower range of recommended doses.

Cessation Of Therapy

When the patient no longer requires therapy with Tapentadol, gradually taper the dose to prevent signs and symptoms of withdrawal in the physically dependent patient.

Instructions For Use

Concentration and Dispensing: The oral solution contains 20 mg Tapentadol per milliliter (mL) and prescriptions should be written in milliliters (mL) and milligrams (mg). An oral syringe is supplied with dose marks corresponding directly to 2.5 mL (equals 50 mg) oral solution, 3.75 mL (equals 75 mg) oral solution, and 5 mL (equals 100 mg) oral solution.

Inform patients of the availability of FDA-approved patient labeling, Instructions for Use, for step-by-step instructions for patients on how to use the medicine bottle and the oral syringe.

How supplied

Dosage Forms And Strengths

active Tapentadol 100 Mg Tablet for sale® oral solution: 20 mg/mL oral solution in 100 mL and 200 mL fill bottles with child-resistant closure.

Tapentadol® oral solution, 20 mg/mL, is available as a clear, colorless solution. Supplied with calibrated syringe:

Bottles of 100 mL (NDC 50458-817-01)

Bottles of 200 mL (NDC 50458-817-02)

Storage And Handling

Store up to 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F). Store the oral solution bottle upright after opening.

Keep Tapentadol® in a secure place out of reach of children.

active Tapentadol 100 Mg Tablet for sale® oral solution that is no longer needed should be destroyed by flushing down the toilet.

Manufactured by: Patheon Pharmaceuticals, Inc. Cincinnati, OH 45237 Manufactured for: Janssen Pharmaceuticals, Inc. Titusville, NJ 08560. Revised: November 2014

Special warnings and precautions for use active Tapentadol 100 Mg Tablet for sale.

Use active Tapentadol 100 Mg Tablet for sale extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tapentadol extended-release tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get active Tapentadol 100 Mg Tablet for sale extended-release tablets refilled.
Take Tapentadol extended-release tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
active Tapentadol 100 Mg Tablet for sale extended-release tablets must only be taken by mouth. Do not inject or snort Tapentadol extended-release tablets.
Do not swallow more than 1 tablet at a time. If your dose requires more than 1 tablet, take only 1 tablet at a time.
Swallow Tapentadol extended-release tablets whole. Do not break, cut, crush, chew, or dissolve the tablet before swallowing it. Contact your doctor if you cannot swallow active Tapentadol 100 Mg Tablet for sale extended-release tablets whole.
Do not presoak, lick, or wet the tablet before you place it in your mouth. Take each tablet with enough water to be sure that it can be completely swallowed immediately after you place it in your mouth.
Do not suddenly stop taking active Tapentadol 100 Mg Tablet for sale extended-release tablets. You may have an increased risk of withdrawal symptoms (eg, nausea, vomiting, diarrhea, anxiety, shivering). If you need to stop Tapentadol extended-release tablets, your doctor will gradually lower your dose.
active Tapentadol 100 Mg Tablet for sale extended-release tablets works best if it is taken at the same time(s) each day. Do not miss any doses.
If you miss a dose of Tapentadol extended-release tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not take more than your prescribed dose in 24 hours.

Ask your health care provider any questions you may have about how to use Tapentadol extended-release tablets.There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications

Neuropathic pain associated with diabetic peripheral neuropathy: Extended-release: Management of neuropathic pain associated with diabetic peripheral neuropathy (DPN) severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Note: Tapentadol ER is generally not recommended as first or second line therapy due to a high risk for addiction and safety concerns compared to modest pain reduction (Pop-Busui 2017).

Tapentadol purchase — without a prescription — ***active Tapentadol 100 Mg Tablet for sale***

Pain management:

Immediate release: Management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate in adults.

Extended release: Management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatments are inadequate.

Limitations of use: Reserve Tapentadol for use in patients for whom alternative treatment options (eg, nonopioid analgesics, opioid combination products) are ineffective, not tolerated, or would be otherwise inadequate to provide sufficient management of pain. active Tapentadol 100 Mg Tablet for sale is not indicated as an as-needed analgesic.

Drug Abuse And Dependence of active Tapentadol 100 Mg Tablet for sale

All patients treated with opioids require careful monitoring for signs of abuse and addiction, because use of opioid analgesic products carries the risk of addiction even under appropriate medical use.

Drug abuse is the intentional non-therapeutic use of an over-the-counter or prescription drug, even once, for its rewarding psychological or physiological effects. Drug abuse includes, but is not limited to the following examples: the use of a prescription or over-the-counter drug to get “high”, or the use of steroids for performance enhancement and muscle build up.

Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and include: a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal.

“Drug seeking” behavior is very common in addicts, and drug abusers. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing or referral, repeated claims of loss of prescriptions, tampering with prescriptions and reluctance to provide prior medical records or contact information for other treating physician(s). “Healthcare professional shopping” (visiting multiple prescribers) to obtain additional prescriptions is common among drug abusers, people suffering from untreated addiction and criminals seeking drugs to sell.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances.

active Tapentadol 100 Mg Tablet for sale® can be diverted for non-medical use into illicit channels of distribution. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required by law, is strongly advised.

Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs.

Dependence

Both tolerance and physical dependence can develop during chronic opioid therapy. Tolerance is the need for increasing doses of opioids to maintain a defined effect such as analgesia (in the absence of disease progression or other external factors). Tolerance may occur to both the desired and undesired effects of drugs, and may develop at different rates for different effects.

Physical dependence results in withdrawal symptoms after abrupt discontinuation or a significant dose reduction of a drug. Withdrawal also may be precipitated through the administration of drugs with opioid antagonist activity, e.g., naloxone, nalmefene, or mixed agonist/antagonist analgesics (pentazocine, butorphanol, buprenorphine, nalbuphine). Physical dependence may not occur to a clinically significant degree until after several days to weeks of continued opioid usage. Some or all of the following can characterize this syndrome: restlessness, lacrimation, rhinorrhea, yawning, perspiration, chills, piloerection, myalgia, mydriasis, irritability, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, increased blood pressure, respiratory rate, or heart rate. Withdrawal symptoms may be reduced by tapering active Tapentadol 100 Mg Tablet for sale®.

Infants born to mothers physically dependent on opioids will also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms.