Order VYVANSE 70 MG CAPSULES online
Order VYVANSE 70 MG CAPSULES online, sold under the brand name Vyvanse among others, is a stimulant medication that is mainly used to treat attention deficit hyperactivity disorder (ADHD) in people over the age of five as well as moderate-to-severe binge eating disorder in adults.[11] Lisdexamfetamine is taken by mouth. Its effects generally begin within 2 hours and last for up to 14 hours.[11][12] In the United Kingdom, it is usually less preferred than methylphenidate.[13]
Common side effects of Order VYVANSE 70 MG CAPSULES online include loss of appetite, anxiety, diarrhea, trouble sleeping, irritability, and nausea.[11] Rare but serious side effects include mania, sudden cardiac death in those with underlying heart problems, and psychosis.[11] It has a high potential for substance abuse per the DEA.[11][12] Serotonin syndrome may occur if used with certain other medications.[11] Its use during pregnancy may result in harm to the baby and use during breastfeeding is not recommended by the manufacturer.[13][11][12]
Order VYVANSE 70 MG CAPSULES online is an inactive prodrug that works after being converted by the body into dextroamphetamine, a central nervous system (CNS) stimulant.[11][14] Chemically, lisdexamfetamine is composed of the amino acid L-lysine, attached to dextroamphetamine.[15]
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Order VYVANSE 70 MG CAPSULES online was approved for medical use in the United States in 2007.[11] In 2019, it was the 79th most commonly prescribed medication in the United States, with more than 9 million prescriptions.[16][17] It is a Class B controlled substance in the United Kingdom and a Schedule II controlled substance in the United States.
An indication is a term used for the list of condition or symptom or illness for which Order VYVANSE 70 MG CAPSULES online is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
Order VYVANSE 70 MG CAPSULES online® is indicated for the treatment of:
- Attention Deficit Hyperactivity Disorder (ADHD)
- Moderate to Severe Binge Eating Disorder (BED).
Limitation of Order VYVANSE 70 MG CAPSULES online
Order VYVANSE 70 MG CAPSULES online is not indicated or recommended for weight loss. Use of other sympathomimetic drugs for weight loss has been associated with serious cardiovascular adverse events. The safety and effectiveness of Elvanse 70mg for the treatment of obesity have not been established.
Order VYVANSE 70 MG CAPSULES online dimesylate is used to treat attention deficit hyperactivity disorder (ADHD) in adults and children 6 years of age and older. Elvanse 70mg dimesylate is also used to treat moderate to severe binge eating disorder (BED). It belongs to the group of medicines called central nervous system (CNS) stimulants.
Order VYVANSE 70 MG CAPSULES online dimesylate increases attention and decreases restlessness in children and adults who are overactive, cannot concentrate for very long, or are easily distracted and impulsive. Elvanse 70mg dimesylate is used as part of a total treatment program that also includes social, educational, and psychological treatment.
Elvanse 70mg dimesylate is available only with your doctor’s prescription.
Pre-treatment Screening for Order VYVANSE 70 MG CAPSULES online
Prior to treating children, adolescents, and adults with CNS stimulants, including Elvanse 70mg, assess for the presence of cardiac disease (e.g., a careful history, family history of sudden death or ventricular arrhythmia, and physical exam).
To reduce the abuse of CNS stimulants including Elvanse 70mg, assess the risk of abuse, prior to prescribing. After prescribing, keep careful prescription records, educate patients about abuse, monitor for signs of abuse and overdose, and re-evaluate the need for Elvanse 70mg use.
General Instructions For Use of Order VYVANSE 70 MG CAPSULES online
Take Elvanse 70mg by mouth in the morning with or without food; avoid afternoon doses because of the potential for insomnia. Elvanse 70mg may be administered in one of the following ways:
- Swallow Order VYVANSE 70 MG CAPSULES online capsules whole, or
- Open capsules, empty and mix the entire contents with yogurt, water, or orange juice. Ifthe contents of the capsule include any compacted powder, a spoon may be used to breakapart the powder. The contents should be mixed until completely dispersed. Consume theentire mixture immediately. It should not be stored. The active ingredient dissolves completely once dispersed; however, a film containing the inactive ingredients may remain in the glass or container once the mixture is consumed. Do not take anything less than one capsule per day, and a single capsule should not be divided.
Dosage For Treatment Of ADHD
The recommended starting dose is 30 mg once daily in the morning in patients ages 6 and above. Dosage may be adjusted in increments of 10 mg or 20 mg at approximately weekly intervals up to maximum dose of 70 mg/day.
Dosage For Treatment Of Moderate To Severe BED In Adults
The recommended starting dose is 30 mg/day to be titrated in increments of 20 mg at approximately weekly intervals to achieve the recommended target dose of 50 to 70 mg/day. The maximum dose is 70 mg/day. Discontinue Order VYVANSE 70 MG CAPSULES online if binge eating does not improve.
Dosage In Patients With Renal Impairment
In patients with severe renal impairment (GFR 15 to < 30 mL/min/1.73 m²), the maximum dose should not exceed 50 mg/day. In patients with end stage renal disease (ESRD, GFR < 15 mL/min/1.73 m²), the maximum recommended dose is 30 mg/day.
Dosage Modifications Due To Drug Interactions
Agents that alter urinary pH can impact urinary excretion and alter blood levels of amphetamine. Acidifying agents (e.g., ascorbic acid) decrease blood levels, while alkalinizing agents (e.g., sodium bicarbonate) increase blood levels. Adjust Order VYVANSE 70 MG CAPSULES online dosage accordingly.
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How supplied
Dosage Forms And Strengths
Capsules 10 mg: pink body/pink cap (imprinted with S489 and 10 mg)
Capsules 20 mg: ivory body/ivory cap (imprinted with S489 and 20 mg)
Capsules 30 mg: white body/orange cap (imprinted with S489 and 30 mg)
Capsules 40 mg: white body/blue green cap (imprinted with S489 and 40 mg)
Capsules 50 mg: white body/blue cap (imprinted with S489 and 50 mg)
Capsules 60 mg: aqua blue body/aqua blue cap (imprinted with S489 and 60 mg)
Capsules 70 mg: blue body/orange cap (imprinted with S489 and 70 mg)
Elvanse 70mg capsules 10 mg: pink body/pink cap (imprinted with S489 and 10 mg), bottles of 100, NDC 59417-101-10
Elvanse 70mg capsules 20 mg: ivory body/ivory cap (imprinted with S489 and 20 mg), bottles of 100, NDC 59417-102-10
Elvanse 70mg capsules 30 mg: white body/orange cap (imprinted with S489 and 30 mg), bottles of 100, NDC 59417-103-10
Elvanse 70mg capsules 40 mg: white body/blue green cap (imprinted with S489 and 40 mg), bottles of 100, NDC 59417-104-10
Elvanse 70mg capsules 50 mg: white body/blue cap (imprinted with S489 and 50 mg), bottles of 100, NDC 59417-105-10
Elvanse 70mg capsules 60 mg: aqua blue body/aqua blue cap (imprinted with S489 and 60 mg), bottles of 100, NDC 59417-106-10
Elvanse 70mg capsules 70 mg: blue body/orange cap (imprinted with S489 and 70 mg), bottles of 100, NDC 59417-107-10
Pharmacodynamics of amphetamine in a dopamine neuron
via AADC
Amphetamine enters the presynaptic neuron across the neuronal membrane or through
Storage And Handling
Dispense in a tight, light-resistant container as defined in the USP.
Store at room temperature, 20°C to 25° C (68°F to 77° F). Excursions permitted between 15°C and 30° C (59 to 86° F).
Disposal
Comply with local laws and regulations on drug disposal of CNS stimulants. Dispose of remaining, unused, or expired Elvanse 70mg by a medicine take-back program.
Manufactured for: Shire US Inc., 300 Shire Way, Lexington, MA 02421. Revised: Oct 2016
Use Elvanse 70mg as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Order VYVANSE 70 MG CAPSULES online comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Elvanse 70mg refilled.
- Take Order VYVANSE 70 MG CAPSULES online by mouth in the morning with or without food.
- Swallow Elvanse 70mg whole. Do not break, crush, or chew before swallowing. If you cannot swallow the capsule whole, you may open it and mix the contents with water. If needed, a spoon may be used to break apart any powder that is stuck together. Stir well until completely mixed. Drink the mixture right away. Do not store the mixture for future use. It is normal to see a filmy coating on the inside of your glass after you take Elvanse 70mg.
- Take Elvanse 70mg on a regular schedule to get the most benefit from it. Taking Order VYVANSE 70 MG CAPSULES online at the same time each day will help you remember to take it.
- If you miss a dose of Elvanse 70mg, take it as soon as possible if you remember that morning. If it is past noon, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Order VYVANSE 70 MG CAPSULES online.There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
Use: Labeled Indications of Order VYVANSE 70 MG CAPSULES online
Attention-deficit/hyperactivity disorder: Treatment of attention-deficit/hyperactivity disorder (ADHD).
Binge eating disorder: Treatment of moderate to severe binge eating disorder in adults.
Drugs Having No Clinically Important Interactions With Elvanse 70mg
From a pharmacokinetic perspective, no dose adjustment of Elvanse 70mg is necessary when Elvanse 70mg is co-administered with guanfacine, venlafaxine, or omeprazole. In addition, no dose adjustment of guanfacine or venlafaxine is needed when Order VYVANSE 70 MG CAPSULES online is co-administered.
From a pharmacokinetic perspective, no dose adjustment for drugs that are substrates of CYP1A2 (e.g. theophylline, duloxetine, melatonin), CYP2D6 (e.g. atomoxetine, desipramine, venlafaxine), CYP2C19 (e.g. omeprazole, lansoprazole, clobazam), and CYP3A4 (e.g. midazolam, pimozide, simvastatin) is necessary when Elvanse 70mg is co-administered.
Drug Abuse And Dependence
Controlled Substance
Order VYVANSE 70 MG CAPSULES online contains Lisdexamfetamine, a prodrug of amphetamine, a Schedule II controlled substance.
Abuse
CNS stimulants, including Order VYVANSE 70 MG CAPSULES online, other amphetamines, and methylphenidate-containing products have a high potential for abuse. Abuse is characterized by impaired control over drug use, compulsive use, continued use despite harm, and craving.
Signs and symptoms of CNS stimulant abuse may include increased heart rate, respiratory rate, blood pressure, and/or sweating, dilated pupils, hyperactivity, restlessness, insomnia, decreased appetite, loss of coordination, tremors, flushed skin, vomiting, and/or abdominal pain. Anxiety, psychosis, hostility, aggression, suicidal or homicidal ideation have also been seen. Abusers of CNS stimulants may chew, snort, inject, or use other unapproved routes of administration which can result in overdose and death.
To reduce the abuse of CNS stimulants, including Order VYVANSE 70 MG CAPSULES online, assess the risk of abuse prior to prescribing. After prescribing, keep careful prescription records, educate patients and their families about abuse and on proper storage and disposal of CNS stimulants, monitor for signs of abuse while on therapy, and re-evaluate the need for Order VYVANSE 70 MG CAPSULES online use.
Studies Of Elvanse 70mg In Drug Abusers
A randomized, double-blind, placebo-control, cross-over, abuse liability study in 38 patients with a history of drug abuse was conducted with single-doses of 50, 100, or 150 mg of Order VYVANSE 70 MG CAPSULES online, 40 mg of immediate-release d-amphetamine sulphate (a controlled II substance), and 200 mg of diethylpropion hydrochloride (a controlled IV substance). Elvanse 70mg 100 mg produced significantly less “Drug Liking Effects” as measured by the Drug Rating Questionnaire-Subject score, compared to d-amphetamine 40 mg; and 150 mg of Elvanse 70mg demonstrated similar “Drug-Liking Effects” compared to 40 mg of d-amphetamine and 200 mg of diethylpropion.
Intravenous administration of 50 mg Elvanse 70mg dimesylate to individuals with a history of drug abuse produced positive subjective responses on scales measuring “Drug Liking”, “Euphoria”, “Amphetamine Effects”, and “Benzedrine Effects” that were greater than placebo but less than those produced by an equivalent dose (20 mg) of intravenous d-amphetamine.
Dependence
Tolerance
Tolerance (a state of adaptation in which exposure to a drug results in a reduction of the drug’s desired and/or undesired effects over time) may occur during the chronic therapy of CNS stimulants including Elvanse 70mg.
Dependence
Physical dependence (a state of adaptation manifested by a withdrawal syndrome produced by abrupt cessation, rapid dose reduction, or administration of an antagonist) may occur in patients treated with CNS stimulants including Elvanse 70mg. Withdrawal symptoms after abrupt cessation following prolonged high-dosage administration of CNS stimulants include extreme fatigue and depression.
Elvanse Adult capsules 50mg and 70mg laid on the packagin
What are the possible side effects of Elvanse 70mg?
The following adverse reactions are discussed in greater detail in other sections of the labeling
- Known hypersensitivity to amphetamine products or other ingredients of Order VYVANSE 70 MG CAPSULES online
- Hypertensive Crisis When Used Concomitantly with Monoamine Oxidase Inhibitors
- Drug Dependence
- Serious Cardiovascular Reactions
- Blood Pressure and Heart Rate Increases
- Psychiatric Adverse Reactions
- Suppression of Growth
- Peripheral Vasculopathy, including Raynaud’s phenomenon
Clinical Trial Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.
Attention Deficit Hyperactivity Disorder
The safety data in this section is based on data from the 4-week parallel-group controlled clinical studies of Elvanse 70mg in pediatric and adult patients with ADHD.
Adverse Reactions Associated With Discontinuation Of Treatment In ADHD Clinical Trials
In the controlled trial in patients ages 6 to 12 years (Study 1), 9% (20/218) of Elvanse 70mg-treated patients discontinued due to adverse reactions compared to 1% (1/72) of placebo-treated patients. The most frequent adverse reactions leading to discontinuation (i.e. leading to discontinuation in at least 1% of Elvanse 70mg-treated patients and at a rate at least twice that of placebo) were ECG voltage criteria for ventricular hypertrophy, tic, vomiting, psychomotor hyperactivity, insomnia, and rash [2 instances for each adverse reaction, i.e., 2/218 (1%)]. In the controlled trial in patients ages 13 to 17 years (Study 4), 4% (10/233) of Elvanse 70mg-treated patients discontinued due to adverse reactions compared to 1% (1/77) of placebo-treated patients. The most frequent adverse reactions leading to discontinuation were irritability (3/233; 1%), decreased appetite (2/233; 1%), and insomnia (2/233; 1%).
In the controlled adult trial (Study 7), 6% (21/358) of Elvanse 70mg-treated patients discontinued due to adverse reactions compared to 2% (1/62) of placebo-treated patients. The most frequent adverse reactions leading to discontinuation (i.e. leading to discontinuation in at least 1% of Elvanse 70mg-treated patients and at a rate at least twice that of placebo) were insomnia (8/358; 2%), tachycardia (3/358; 1%), irritability (2/358; 1%), hypertension (4/358; 1%), headache (2/358; 1%), anxiety (2/358; 1%), and dyspnea (3/358; 1%).
The most common adverse reactions (incidence ≥ 5% and at a rate at least twice placebo) reported in children, adolescents, and/or adults were anorexia, anxiety, decreased appetite, decreased weight, diarrhea, dizziness, dry mouth, irritability, insomnia, nausea, upper abdominal pain, and vomiting.
Adverse Reactions Occurring At An Incidence Of 2% Or More Among Elvanse 70mg Treated Patients With ADHD In Clinical Trials
Adverse reactions reported in the controlled trials in pediatric patients ages 6 to 12 years (Study 1), adolescent patients ages 13 to 17 years (Study 4), and adult patients (Study 7) treated with Elvanse 70mg or placebo are presented in Tables 1, 2, and 3 below.
Table 1 : Adverse Reactions Reported by 2% or More of Children (Ages 6 to 12 Years)with ADHD Taking Elvanse 70mg and at least Twice the Incidence in PatientsTaking Placebo in a 4-Week Clinical Trial (Study 1)
