order super quality danazol 20mg

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order super quality danazol 20mg Capsule is used for Endometriosis, Fibrocystic breast disease, Hereditary angioedema and other conditions.

Description

order super quality danazol 20mg

order super quality danazol 20mg capsules, sold as Danocrine and other brand names, is a medication used in the treatment of endometriosisfibrocystic breast diseasehereditary angioedema and other conditions.[8][1][9][10][11] It is taken by mouth.[1] The use of order super quality danazol 20mg is limited by masculinizing side effects such as acneexcessive hair growth, and voice deepening.[1][12] Danazol has a complex mechanism of action, and is characterized as a weak androgen and anabolic steroid, a weak progestogen, a weak antigonadotropin, a weak steroidogenesis inhibitor, and a functional antiestrogen.

Components of order super quality danazol 20mg:

Method of action for Danazol 20mg quality capsules:

Treatment option.

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order super quality danazol 20mg Qualitative and quantitative composition

  Each capsule contains 100 mg danazol. Excipient with known effect: Each capsule contains 45 mg lactose.Pharmaceutical form Danazol 20mg quality capsules. Size 3 capsule, light grey body, dark grey cap, marked in black “DL 100” and “G”Therapeutic indication order super quality danazol 20mg capsules are recommended for the treatment of: 1. Endometriosis. To control pain, pelvic tenderness and other associated symptoms and to resolve or reduce the extent of endometriotic foci. Danazol 20mg quality capsules may be used as sole therapy, in preparation for or following surgery or in patients not responding to other treatments. 2. Dysfunctional uterine bleeding presenting as menorrhagia. To control excessive blood loss and to control associated dysmenorrhoea. 3. For the treatment of severe cyclical mastalgia with or without nodularity (fibrocystic disease) unresponsive to counselling or simple analgesics. To reduce pain, tenderness and nodularity. 4. For the control of benign, multiple or recurrent breast cysts in conjunction with aspiration. 5. Severe symptomatic gynaecomastia, both idiopathic as well as drug induced, to reduce the size of the breast and to control associated pain and tenderness. 6. Pre-operative thinning of the endometrium prior to hysteroscopic endometrial ablation.
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Dosage (Posology) and method of administration for order super quality danazol 20mg capsules

Adults The usual range of order super quality danazol 20mg capsules uses dosage is 200 mg to 800 mg daily in up to four divided doses. order super quality danazol 20mg capsules should be given as a continuous course, dosage being adjusted according to the severity of the condition and the patient’s response. A reduction in dosage once a satisfactory response has been achieved may prove possible. In fertile females, order super quality danazol 20mg should be started during menstruation, preferably on the first day, to avoid exposing a pregnancy to its possible effects. Where doubt exists, appropriate checks should be made to exclude pregnancy before starting medication. Females of child-bearing age should employ non-hormonal contraception throughout the course of treatment. In endometriosis, the recommended dosage order super quality danazol 20mg capsules is 200-800 mg daily in a course of treatment lasting normally three to six months, although up to nine months may be necessary in some cases. Dosage should be increased if normal cyclical bleeding still persists after two months therapy, a higher dosage (not exceeding 800 mg per day) may also be needed for severe disease. For dysfunctional uterine bleeding presenting as menorrhagia, the dosage should be 200 mg daily, normally for 3 months. How we are endosed with amazone In severe cyclical mastalgia, treatment should commence at a dose of 200-300 mg daily, according to the severity of the symptoms, a course of treatment normally lasting 3-6 months. In benign breast fibrocystic disease, treatment should commence at a dose of 300 mg daily, a course of treatment normally lasting 3 to 6 months. In gynaecomastia a six-month course of therapy is recommended at a dose of 200 mg daily in adolescents which may be increased to 400 mg daily if no response is obtained after two months. Adults may be given 400 mg daily. For pre-operative thinning of the endometrium, the usual dose is 400-800 mg daily given as a continuous course normally lasting 3-6 weeks. Elderly order super quality danazol 20mg Capsules are not recommended. Paediatric population Danazol 20mg quality capsules are not recommended. Method of administration For oral administration only.
 

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Special warnings and precautions for use order super quality danazol 20mg capsules uses In view of its pharmacology, known interactions and side effects, particular care should be observed when using order super quality danazol 20mg in patients with hepatic or renal disease, hypertension or other cardiovascular disease and in any state which may be exacerbated by fluid retention as well as in diabetes mellitus, polycythaemia, epilepsy, lipoprotein disorder, in those with a history of thrombosis, and in those who have shown marked or persistent androgenic reaction to previous gonadal steroid therapy. Adjustment in concomitant therapy may be called for particularly in patients with hypertension, diabetes mellitus or epilepsy when introducing or discontinuing danazol as well as during Danazol treatment. Caution is advised in patients with migraine order super quality danazol 20mg capsules Until more is known, caution is advised in the use of Danazol 20mg quality capsules in the presence of known or suspected malignant disease (see also contraindications).
 
Before treatment initiation, the presence of hormone-dependent carcinoma should be excluded at least by careful clinical examination, as well as if breast nodules persist or enlarge during danazol treatment. In the event of virilisation, order super quality danazol 20mg quality capsules should be withdrawn. Whilst androgenic reactions will generally prove reversible, continued use of danazol in the face of evident virilisation is likely to cause irreversible androgenic effects. order super quality danazol 20mg capsules should be stopped if any clinically significant adverse event arises, and particularly if there is evidence of papilloedema, headache, visual disturbances or other signs or symptoms of raised intracranial pressure, jaundice or other indication of significant hepatic disturbance, thrombosis or thromboembolism. In addition to clinical monitoring in all patients, appropriate laboratory monitoring should be considered which may include periodic measurement of hepatic function and haematological state. For long-term treatment (> 6 months) or repeated courses of treatment, biannual hepatic ultrasonography is recommended.
 
order super quality danazol 20mg capsules should be initiated during menstruation. An effective, non-hormonal method of contraception should be employed. The lowest effective dose of danazol should always be sought. Experience of long term therapy with danazol is limited. Whilst a course of therapy may need to be repeated, care should be observed as no safety data are available in relation to repeated courses of treatment over time. The long-term risk of 17-alkylated steroids (including benign hepatic adenomata, hepatocellular focal nodular hyperplasia, peliosis hepatis and hepatic carcinoma), should be considered when danazol, which is chemically related to these compounds, is used for periods longer than those normally recommended. Data, from two case-control epidemiological studies, were pooled to examine the relationship between endometriosis, endometriosis treatments and ovarian cancer. These preliminary results suggest that the use of danazol might increase the baseline risk of ovarian cancer in – patients treated for endometriosis. order super quality danazol 20mg capsules contain lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
 
Undesirable effects of order super quality danazol 20mg capsules The possible causal relationship between danazol and many of the following events reportedly associated with its use remains to be defined. Blood and lymphatic system disorders Increase in red cell and platelet count. Reversible erythrocytosis or polycythaemia may be provoked. Eosinophilia, leucopenia, splenic peliosis and thrombocytopenia have also been noted. Endocrine disorders Androgenic effects: Acne, weight gain, increased appetite, seborrhoea, hirsutism, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch. Hypertrophy of the clitoris, fluid retention. Other endocrine effects: Menstrual disturbances in the form of spotting, alteration of the timing of the cycle and amenorrhoea. Flushing, vaginal dryness, vaginal irritation and reduction in breast size. Vaginal dryness and irritation and reduction in breast size may reflect a lowering of oestrogen. Although cyclical bleeding and ovulation usually return within 60-90 days after danazol, persistent amenorrhoea has occasionally been reported. Modest reduction in spermatogenesis.

 

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Metabolism and nutrition disorders Insulin resistance may be increased in diabetes mellitus but symptomatic hypoglycaemia in non-diabetic patients has also been reported as an increase in plasma glucagon level, mild impairment of glucose tolerance. A temporary alteration of lipoproteins in the form of an increase in LDL cholesterol, a decrease in HDL cholesterol, affecting all subfractions, and a decrease in apolipoproteins A1 and AII. The clinical significance of these changes is not established. Induction of aminolevulinic acid (ALA) synthetase, and reduction in thyroid binding globulin, T4, with increased uptake of T3 but without disturbance of thyroid stimulating hormone or free thyroxin index, is also likely during therapy. Psychiatric disorders Emotional lability, anxiety, depressed mood, nervousness and changes in libido.
 
Nervous system disorders Dizziness, headache, vertigo, benign intracranial hypertension. order super quality danazol 20mg may aggravate epilepsy and expose the condition in those so predisposed. Fluid retention may explain the occasional reports of carpal tunnel syndrome. Danazol may also provoke migraine. Eye disorders Visual disturbances which may take the form of blurring or difficulty in focusing and in wearing contact lenses or need for temporary alteration in refractive correction have been noted. Cardiac disorders Hypertension, palpitation and tachycardia. Thrombotic events including sagittal sinus, cerebrovascular thrombosis as well as arterial thrombosis. Myocardial infarction. Vascular disorders Flushing, exacerbation of hypertension Respiratory, thoracic and mediastinal disorders Pleuritic pain, interstitial pneumonitis Gastrointestinal disorders Nausea, epigastric pain Hepatobiliary disorders Modest increase in serum transaminase levels and rarely cholestatic jaundice, benign hepatic adenomata and pancreatitis. Peliosis hepatis as well as malignant hepatic tumour have been observed with long term use. Hepatocellular injury, hepatic failure, jaundice hepatocellular, hepatocellular focal nodular hyperplasia. Skin and subcutaneous tissue disorders Rashes, which may be maculopapular, petechial, or purpuric or may take an urticarial form and may be accompanied by facial oedema. Associated fever has also been reported. Rarely, sun-sensitive rash has been noted. Inflammatory erythematous nodules, changes in skin pigmentation, exfoliative dermatitis and erythema multiforme have also been reported.
Danocrine - (Danazol) - Generic
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Musculoskeletal and connective tissue disorders Backache and muscle cramps which can be severe. Creatine phosphokinase levels may also rise. Muscle tremors, fasciculation, limb pain, joint pain and joint swelling have also been reported. Renal and urinary disorders Haematuria has rarely been reported with prolonged use in patients with hereditary angioedema. General disorders and administration site conditions Fatigue Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Pharmacokinetic properties of order super quality danazol 20mg capsules Absorption Danazol is absorbed from the gastrointestinal tract, peak plasma concentrations of 50-80ng/ml being reached approximately 2-3 hours after dosing. Compared to the fasting state, the bioavailability has been shown to increase 3 fold when the drug is taken with a meal with a high fat content. It is thought that food stimulates bile flow which facilitates the dissolution and absorption of danazol, a highly lipophilic compound.
 
A dose of danazol 100 mg twice daily gives a steady state plasma level in 7 days but a dose of 200 mg twice daily does not give a steady state plasma level unit 14 days. The apparent plasma elimination half life of danazol in a single dose is approximately 3-6 hours. With multiple doses this may increase to approximately 26 hours. Biotransformation In humans, 2-hydroxymethylethisterone and ethisterone are the major urinary metabolites with unchanged danazol absent. The antigonadotrophic activity of danazol appears to be exerted by the unchanged compound and not by one of its metabolites, for the major metabolites are devoid of antigonadotrophic action. The activity of danazol is slightly increased when it is administered with substances which inhibit the action of drug-metabolising enzymes. None of the metabolites of danazol, which have been isolated, exhibits pituitary inhibiting activity comparable to that of danazol. Elimination Few data on excretion routes and rates exist. In the monkey 36% of a radioactive dose was recoverable in the urine and 48% in the faeces within 96 hours. Fertility, pregnancy and lactation of order super quality danazol 20mg capsules Pregnancy There is epidemiological and toxicological evidence of hazard in human pregnancy.
 
order super quality danazol 20mg is known to be associated with the risk of virilisation to the female foetus if administered during human pregnancy. order super quality danazol 20mg should not be used during pregnancy. Women of childbearing age should be advised to use an effective, non-hormonal, method of contraception. If the patient conceives during therapy, Danazol should be stopped. Breast-feeding Danazol has the theoretical potential for androgenic effects in breast-fed infants and therefore either Danazol therapy or breastfeeding should be discontinued. Danazol Capsules are available either in polypropylene containers with polyethylene caps and optional polyethylene ullage filler, PVdC/aluminium foil blisters, HDPE containers with polyethylene snap closures. The pack sizes available in all pack types are 28, 30, 50, 56, 60, 84, 90, 100, 112 and 250. Not all pack sizes may be marketed. Capsule: – lactose monohydrate – cellulose, microcrystalline – silica, colloidal anhydrous – povidone K30 – lactose anhydrous – sodium starch glycolate – sodium laurilsulfate – magnesium stearate Capsule shell: – gelatin – titanium dioxide (E171) – iron oxide black (E172) Available evidence suggests that acute overdosage would be unlikely to give rise to immediate serious reaction. In the case of acute overdosage consideration should be given to reducing the absorption of the drug with activated charcoal, and the patient should be kept under observation in case of any delayed reactions. Special warnings and precautions for use In view of its pharmacology, known interactions and side effects, particular care should be observed when using danazol in patients with hepatic or renal disease, hypertension or other cardiovascular disease and in any state which may be exacerbated by fluid retention as well as in diabetes mellitus, polycythaemia, epilepsy, lipoprotein disorder, in those with a history of thrombosis, and in those who have shown marked or persistent androgenic reaction to previous gonadal steroid therapy.
 
Adjustment in concomitant therapy may be called for particularly in patients with hypertension, diabetes mellitus or epilepsy when introducing or discontinuing danazol as well as during Danazol treatment. Caution is advised in patients with migraine. Until more is known, caution is advised in the use of order super quality danazol 20mg in the presence of known or suspected malignant disease (see also contraindications). Before treatment initiation, the presence of hormone-dependent carcinoma should be excluded at least by careful clinical examination, as well as if breast nodules persist or enlarge during danazol treatment. In the event of virilisation, Danazol should be withdrawn. Whilst androgenic reactions will generally prove reversible, continued use of danazol in the face of evident virilisation is likely to cause irreversible androgenic effects. order super quality danazol 20mg should be stopped if any clinically significant adverse event arises, and particularly if there is evidence of papilloedema, headache, visual disturbances or other signs or symptoms of raised intracranial pressure, jaundice or other indication of significant hepatic disturbance, thrombosis or thromboembolism. In addition to clinical monitoring in all patients, appropriate laboratory monitoring should be considered which may include periodic measurement of hepatic function and haematological state. For long-term treatment (> 6 months) or repeated courses of treatment, biannual hepatic ultrasonography is recommended. order super quality danazol 20mg should be initiated during menstruation. An effective, non-hormonal method of contraception should be employed. The lowest effective dose of danazol should always be sought.
 
Experience of long term therapy with danazol is limited. Whilst a course of therapy may need to be repeated, care should be observed as no safety data are available in relation to repeated courses of treatment over time. The long-term risk of 17-alkylated steroids (including benign hepatic adenomata, hepatocellular focal nodular hyperplasia, peliosis hepatis and hepatic carcinoma), should be considered when danazol, which is chemically related to these compounds, is used for periods longer than those normally recommended. Data, from two case-control epidemiological studies, were pooled to examine the relationship between endometriosis, endometriosis treatments and ovarian cancer. These preliminary results suggest that the use of order super quality danazol 20mg might increase the baseline risk of ovarian cancer in – patients treated for endometriosis. order super quality danazol 20mg capsules contain lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
 
 
 
 
 
 
 
 
 

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Danazol

200mg, 200mg, 200mg, 200mg, 200mg, 100mg, 100mg, 100mg, 100mg, 100mg, 50mg, 50mg, 50mg, 50mg, 50mg

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